What GHRP-2 is
More potent successor to GHRP-6. D-2-naphthylalanine substitution increases binding affinity. Approved in Japan as pralmorelin (GHRP Kaken 100) for GH deficiency testing.
Mechanism, in plain English
Activates ghrelin receptor on pituitary, triggering GH release while suppressing somatostatin. Produces ~20-30% more GH than GHRP-6 at equivalent doses. Moderate appetite stimulation (less than GHRP-6, more than ipamorelin).
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Highest peak GH levels among GHRP family in comparative studies. Japanese diagnostic approval provides more human pharmacokinetic and safety data than most research peptides. No large therapeutic trials for anti-aging or performance.
FDA status
Not FDA-approved in US. Approved in Japan as pralmorelin.
Common synonyms
GHRP-2, pralmorelin, KP-102, GHRP Kaken 100
Safety and adverse-event landscape
Well-characterized in diagnostic use. Appetite increase (moderate), cortisol and prolactin elevation, water retention.
Frequently asked questions
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